Famotidine is a potent histamine H2-receptor antagonist with antiulcer activity. It inhibits gastric acid secretion and reduces the overall acidity of the stomach. Famotidine is commonly used to treat ulcers, gastroesophageal reflux disease (GERD), and other related conditions. Its chemical properties make it an effective and reliable option for managing digestive issues.
Famotidine Chemical Properties Article
Famotidine is a compound with interesting chemical properties. It is a histamine H2-receptor antagonist that inhibits gastric acid secretion. This property makes famotidine useful in the treatment of various gastrointestinal conditions.
Physical Properties
Famotidine is a white to pale yellow crystalline powder with a molecular weight of 337.43 g/mol.
It is a practically odorless compound with a melting point of approximately 163-167°C.
Its solubility in water is about 0.34 mg/mL at 25°C.
Chemical Structure
The chemical structure of famotidine includes a thiazole ring with a sulfur atom and a nitrogen atom, as well as a guanidine group.
Chemical Structure
Famotidine is a histamine H2-receptor antagonist with the chemical formula C8H15N7O2S3. It has a molecular weight of 337.44 g/mol and is a white to pale yellow crystalline powder. The chemical structure of famotidine consists of a sulfamoyl group attached to a furan ring with a substituted thiazole ring. The molecule has two nitrogen atoms that are basic and capable of forming hydrogen bonds with the histamine receptor.
The structure of famotidine plays a crucial role in its pharmacological activity, as it allows the molecule to bind selectively to the histamine H2-receptor on gastric parietal cells, thereby inhibiting the secretion of gastric acid. This mechanism of action makes famotidine an effective treatment for conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers.
Chemical Structure
Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production. Its chemical structure is composed of a thiazole ring with a sulfur atom at position 2 and a methyl group at position 4. The structure also includes an amino group attached to an N1-imidazole ring. This unique arrangement allows famotidine to interact with histamine receptors in the stomach, preventing the release of acid and providing relief from heartburn and acid reflux.
Acid-Base Properties
Famotidine is a compound with interesting acid-base properties. It is a histamine H2-receptor antagonist that inhibits stomach acid production by targeting proton pumps. Famotidine acts as a weak base, meaning it can accept a proton (H+) to form a positively charged species.
Due to its basic nature, famotidine can interact with acidic environments, such as the stomach, where it can neutralize excess acid and provide relief for conditions like heartburn or acid reflux. This property makes famotidine a valuable component in medications designed to treat gastrointestinal issues related to excessive acidity.
Solubility
Famotidine has limited solubility in water, with a solubility of approximately 0.1 mg/mL at room temperature. However, it is more soluble in acidic solutions, which makes it more bioavailable in the stomach, where it is primarily used to treat acid-related conditions.
The solubility of Famotidine can be influenced by factors such as pH, temperature, and the presence of other substances in the solution. It is important to note that Famotidine should be stored in a cool, dry place away from direct sunlight to maintain its stability and solubility.
| pH | Solubility (mg/mL) |
|---|---|
| 2 | 2.5 |
| 5 | 0.5 |
| 7 | 0.1 |
Stability
Famotidine is a stable compound under normal storage conditions. It should be stored in a cool, dry place away from direct sunlight and heat sources. The compound is stable in both solid and liquid forms.
Storage Recommendations
- Store famotidine at room temperature (20-25°C).
- Avoid exposure to high temperatures and moisture.
- Keep the medication in its original packaging to protect it from light.
Overall, famotidine demonstrates good stability, making it a reliable choice for pharmaceutical use.