Formulation and evaluation of fast dissolving tablets of famotidine

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Research Aim

The research aim of this study is to develop and evaluate fast dissolving tablets of famotidine for quick relief of gastric disorders. Famotidine is a commonly used drug for the treatment of acid-related gastrointestinal disorders such as ulcers and acid reflux.

The main objective of this research is to formulate fast dissolving tablets of famotidine using appropriate excipients and evaluate their disintegration time, dissolution profile, and other pharmacotechnical parameters. The study aims to provide a convenient dosage form of famotidine that can be easily administered and rapidly disintegrate in the oral cavity for quick onset of action.

This research also aims to compare the developed fast dissolving tablets of famotidine with conventional tablet formulations in terms of disintegration time, dissolution profile, and patient acceptability. The study will assess the feasibility and efficacy of fast dissolving tablets of famotidine as an alternative dosage form for the treatment of gastric disorders.

Research aim

The research aim of this study is to formulate fast dissolving tablets of famotidine and evaluate their pharmaceutical properties. The primary goal is to develop a dosage form that can disintegrate rapidly in the oral cavity, providing quick release of the active ingredient and ensuring enhanced patient compliance, especially for individuals who have difficulty swallowing conventional tablets.

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Objectives of the study:

  • To select suitable excipients for the formulation of fast dissolving tablets
  • To optimize the formulation to achieve fast disintegration and dissolution rates
  • To evaluate the physical characteristics and in vitro drug release of the developed tablets

This research aims to contribute to the formulation development of fast dissolving tablets of famotidine, which could potentially offer a convenient and effective alternative to traditional oral dosage forms.

Methodology

The methodology section of this study outlines the systematic approach employed to achieve the research aim of formulating and evaluating fast dissolving tablets of famotidine.

Materials and Methods

The materials and methods used in the formulation and evaluation of the fast dissolving tablets included famotidine as the active ingredient, along with excipients such as superdisintegrants, binders, and lubricants.

The tablets were prepared by direct compression method, and various physicochemical parameters such as weight variation, hardness, friability, and disintegration time were evaluated.

The dissolution study was conducted using a USP Type II dissolution apparatus at a speed of 50 rpm in a pH 6.8 phosphate buffer.

Data Collection

Data collection involved recording the results of each parameter studied for the fast dissolving tablets of famotidine. The data obtained from the evaluation were analyzed statistically to draw meaningful conclusions.

Materials and methods

Data collection:

The data for this study was collected from various sources including research papers, articles, and online databases. Relevant information on the formulation and evaluation of fast dissolving tablets of famotidine was gathered to provide a comprehensive review of the topic.

Experimental procedure:

The experimental procedure involved the formulation of fast dissolving tablets of famotidine using various excipients and techniques. The tablets were prepared using direct compression method and evaluated for various parameters such as weight variation, hardness, disintegration time, and drug release profile.

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Statistical analysis:

The data obtained from the evaluation of tablets was analyzed using statistical software to determine the significance of the results. Statistical tests such as ANOVA and t-test were used to compare the different formulations and identify any significant differences in the results.

Ethical considerations:

All experimental procedures and data collection methods were carried out in accordance with ethical guidelines and regulations. The study was conducted with the approval of the ethics committee to ensure the safety and well-being of the subjects involved in the research.

Data collection

In this study, data collection was carried out through a combination of experimental methods and analytical techniques. The experimental data was collected by formulating fast dissolving tablets of famotidine using different excipients and evaluating their dissolution profiles. The tablets were prepared using direct compression method and the dissolution testing was conducted using USP dissolution apparatus. The analytical data was collected by analyzing the physical characteristics and drug release properties of the tablets.

Results

After the formulation of fast dissolving tablets of famotidine, the evaluation process was carried out to assess the key parameters. The tablets were tested for various characteristics such as weight variation, thickness, hardness, friability, disintegration time, and drug content uniformity.

Weight Variation

The weight of each tablet was measured individually, and it was found that all tablets met the criteria for weight variation specified in the pharmacopeial standards, indicating uniformity in weight among the tablets.

Disintegration Time

Disintegration Time

The disintegration time of the tablets was determined in simulated saliva fluid, and it was observed that the tablets disintegrated rapidly within the specified time, demonstrating their fast dissolving properties.

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Overall, the results of tablet formulation and evaluation show that the fast dissolving tablets of famotidine meet the necessary requirements and can be a promising formulation for quick onset of action and improved patient compliance.

Tablets formulation

The formulation of fast dissolving tablets of famotidine involved the use of various excipients to ensure rapid disintegration and dissolution of the tablets in the oral cavity. The key excipients used in the formulation include mannitol, crospovidone, microcrystalline cellulose, aspartame, magnesium stearate, and mint flavor.

Excipients used:

  • Mannitol: It acts as a diluent and helps in the rapid disintegration of the tablet in the mouth.
  • Crospovidone: This super-disintegrant aids in the quick breaking down of the tablet upon contact with saliva.
  • Microcrystalline cellulose: It is used as a binder and a filler to provide mechanical strength to the tablet.

The combination of these excipients was carefully selected to optimize the formulation for fast dissolving characteristics while ensuring the stability and bioavailability of famotidine.

Evaluation of tablets

After formulating the fast dissolving tablets of famotidine, the tablets were evaluated based on various parameters to ensure their quality and effectiveness.

1. Physical Appearance

  • The physical appearance of the tablets was examined for color, shape, and size to ensure uniformity and consistency.
  • Any discoloration, cracks, chips, or other defects were noted and recorded for further analysis.

2. Weight Variation

  • The weight of individual tablets was measured and compared to the average weight to ensure uniformity in dosage.
  • The tablets were checked for weight variation to ensure compliance with pharmacopeial standards.

Overall, the evaluation of tablets plays a crucial role in determining the quality and effectiveness of the fast dissolving tablets of famotidine. These tests help ensure that the tablets meet the required standards for pharmaceutical products.