Mekanisme kerja obat famotidine

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Famotidine is a type of medication known as a histamine-2 blocker. It works by decreasing the amount of acid your stomach produces, which helps to relieve symptoms of heartburn, acid reflux, and other stomach-related issues.

When you take famotidine, it blocks the histamine receptors in the stomach, reducing the production of acid. This can help to prevent and treat conditions such as gastritis, ulcers, and gastroesophageal reflux disease (GERD).

Consult your healthcare provider before taking famotidine to ensure it is right for you and to determine the appropriate dosage.

Mechanism of Action

Famotidine is a histamine H2-receptor antagonist that inhibits the action of histamine at the H2 receptors of the stomach. By blocking these receptors, famotidine reduces the production of gastric acid, leading to decreased acidity in the stomach and relief from symptoms of acid-related conditions.

How it works

When famotidine is ingested, it selectively inhibits the H2 receptors on the parietal cells in the stomach lining, which are responsible for producing gastric acid. By blocking these receptors, famotidine decreases the production of acid, thereby reducing the acidity in the stomach and providing relief from symptoms such as heartburn, acid indigestion, and gastroesophageal reflux disease (GERD).

Famotidine’s mechanism of action: inhibits histamine H2 receptors, reduces gastric acid production, decreases stomach acidity, provides relief from acid-related symptoms.

Mechanism of Action

Famotidine is a competitive inhibitor of histamine H2-receptors. It suppresses the secretion of stomach acid by blocking the binding of histamine to the H2 receptors on the parietal cells in the stomach. This leads to a decrease in basal and stimulated gastric acid secretion. Famotidine also inhibits pepsin secretion stimulated by histamine and gastrin.

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Famotidine Binding

When famotidine binds to the H2-receptors, it forms a stable complex that prevents histamine from activating the receptor. This inhibition of histamine action results in a reduction of gastric acid secretion, providing relief for conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers.

In summary, famotidine exerts its therapeutic effects by targeting the histamine H2-receptors in the stomach, resulting in decreased gastric acid production and improved symptoms of acid-related disorders.


Famotidine is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-3 hours. It is primarily metabolized in the liver, with approximately 35-45% of the dose excreted unchanged in the urine. The elimination half-life is around 2.5-3.5 hours in healthy individuals, but may be prolonged in patients with impaired renal function.


Metabolism of famotidine primarily occurs in the liver, where it is metabolized by oxidation, demethylation, and sulfoxidation. The main metabolite, S-oxide famotidine, is pharmacologically inactive.


Approximately 35-45% of a dose is excreted unchanged in the urine, with the remainder excreted as metabolites in both the urine and feces. Renal excretion is the primary route of elimination, and dose adjustments may be necessary in patients with impaired renal function.

Indications for Use

Famotidine is indicated for the treatment of:

– Duodenal ulcer

– Gastric ulcer

– Gastroesophageal reflux disease (GERD)

– Zollinger-Ellison syndrome

– Erosive esophagitis

– Heartburn

– Prevention of gastrointestinal ulcers in patients at risk

Side Effects

It is important to be aware of the potential side effects of using Famotidine. While most people do not experience any serious side effects, some common side effects may include:

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Mild side effects:

Mild side effects:

– Headache

– Dizziness

– Nausea

– Diarrhea

Serious side effects:

– Allergic reactions such as rash, itching, swelling of the face, tongue, or throat

– Difficulty breathing or swallowing

– Chest pain

– Irregular heartbeat

If you experience any of these serious side effects, it is important to seek medical attention immediately. Remember to consult your healthcare provider if you have any concerns about the side effects of Famotidine.

Dosage and Administration

Dosage and Administration

It is recommended to take famotidine orally, usually once or twice daily. The dosage may vary depending on the condition being treated and the individual response to the medication. It is important to follow the instructions provided by your healthcare provider or pharmacist carefully.

Adult Dosage: The typical adult dose for treating conditions like GERD is 20-40 mg taken once or twice daily. The dosage may be adjusted based on the severity of the condition and the response to treatment.

Children Dosage: The dosage for children may be based on their weight and specific condition. It is important to consult with a healthcare provider to determine the appropriate dosage for children.

Administration: Famotidine can be taken with or without food. It is recommended to take the medication with a full glass of water to help with swallowing and absorption. Do not crush, chew, or break the tablets unless instructed to do so by a healthcare provider.

It is important to take famotidine as directed and not to exceed the recommended dosage without consulting a healthcare provider.

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