Molecular structure of famotidine

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Famotidine is a powerful medication used to treat acid-related conditions in the stomach. Its molecular structure consists of various elements arranged in a specific pattern that gives it its unique properties.

Discover the magic of famotidine’s molecular structure and how it can help you find relief from heartburn, acid reflux, and other digestive issues. With its precise composition, famotidine targets the root causes of acidity and provides long-lasting relief.

Explore the molecular world of famotidine and experience the difference it can make in your day-to-day life. Say goodbye to discomfort and hello to a happier, healthier you with famotidine!

Molecular Composition and Properties

Famotidine is a potent inhibitor of gastric acid secretion that belongs to the H2-receptor antagonists class of drugs. Its molecular formula is C8H15N7O2S3 and its molecular weight is approximately 337.48 g/mol.

The chemical structure of famotidine consists of a thiazole ring attached to a sulfur and an aminoethylsulfanyl group. This structure enables famotidine to competitively block the H2 receptors on the parietal cells of the stomach, thereby reducing the production of gastric acid.

Famotidine is a white to pale yellow crystalline powder with a slight sulfur-like odor. It is sparingly soluble in water and methanol but more soluble in acidic solutions. The drug has a pKa value of about 7.6, indicating that it is a weak base in nature.

Important Note:

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As with any medication, it is essential to consult a healthcare professional before using famotidine, especially if you have underlying health conditions or are taking other medications.

Chemical Composition and Properties

Chemical Composition and Properties

Famotidine, also known by its brand name Pepcid, is a histamine H2 receptor antagonist that inhibits stomach acid production. Its chemical formula is C8H15N7O2S3, indicating its molecular composition containing carbon, hydrogen, nitrogen, oxygen, and sulfur.

Structural Formula

The structural formula of famotidine depicts the arrangement of atoms in the molecule, illustrating the interconnectedness of carbon, hydrogen, nitrogen, oxygen, and sulfur atoms. This structure is crucial for understanding the drug’s pharmacological properties and interactions in the body.


Famotidine is a white to pale yellow crystalline solid with a melting point of approximately 163-167°C. It is sparingly soluble in water and ethanol, but more soluble in methanol. The compound has a pKa value of 0.7 for the acidic NH group and 7.5 for the basic nitrogen atom, indicating its potential ionization behavior in different environments.

Structural Formula of Famotidine

Famotidine, chemically known as 3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]-N’-sulfamoylpropanimidamide, has a complex structural formula. It consists of a thiazole ring attached to a sulfamoyl group and an amidine group.

Key Features:

  • The thiazole ring provides stability and contributes to the pharmacological activity of famotidine.
  • The sulfamoyl group enhances the potency of the drug by forming hydrogen bonds with the target receptor.
  • The amidine group plays a crucial role in binding to the histamine H2 receptor, inhibiting acid secretion in the stomach.

The structural formula of famotidine illustrates the precise arrangement of atoms and functional groups that are essential for its biological activity. Understanding the molecular structure helps in comprehending the drug’s mechanism of action and how it interacts with its target in the body.

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Pharmacological Features of Famotidine

Pharmacological Features of Famotidine

Famotidine is a histamine-2 receptor antagonist that works by decreasing the amount of acid produced in the stomach. It is commonly used to treat conditions such as gastroesophageal reflux disease (GERD), ulcers, and heartburn. Famotidine helps relieve symptoms such as indigestion, acid reflux, and stomach pain by reducing the production of stomach acid.

Furthermore, famotidine can also be used as a preventive medication to reduce the risk of stomach ulcers in individuals taking nonsteroidal anti-inflammatory drugs (NSAIDs) on a long-term basis. By blocking the histamine-2 receptors, famotidine helps to protect the stomach lining from damage caused by excessive acid production.

It is important to follow the prescribed dosage and instructions provided by a healthcare provider when taking famotidine to ensure its effectiveness and minimize potential side effects. Consult a healthcare professional for personalized advice on the appropriate use of famotidine based on individual health conditions and needs.

Overall, famotidine’s pharmacological properties make it a valuable medication for managing various gastrointestinal conditions and promoting stomach health.

Medical Applications of Famotidine

Famotidine is primarily used to treat conditions related to excess stomach acid production, such as gastroesophageal reflux disease (GERD), ulcers, and Zollinger-Ellison syndrome. It belongs to a class of medications known as H2-receptor antagonists, which work by decreasing the amount of acid produced in the stomach.

Treatment of GERD

GERD is a chronic condition characterized by the backflow of stomach acid into the esophagus, leading to symptoms such as heartburn, chest pain, and difficulty swallowing. Famotidine helps alleviate these symptoms by reducing the production of stomach acid and promoting healing of the esophagus lining.

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Ulcer Healing

Famotidine is also effective in treating peptic ulcers, which are open sores that develop on the lining of the stomach or duodenum due to excessive acid production or infection with Helicobacter pylori bacteria. By reducing stomach acid levels, famotidine allows ulcers to heal and prevents their recurrence.

Medical Condition Treatment
Gastroesophageal Reflux Disease (GERD) Acid reduction, symptom relief, and esophagus healing
Peptic Ulcers Promoting ulcer healing and preventing recurrence